Asunto(s)
Alopecia/etiología , Enfermedad Injerto contra Huésped/complicaciones , Dermatosis del Cuero Cabelludo/complicaciones , Adulto , Alopecia/patología , Enfermedad Crónica , Dermoscopía , Enfermedad Injerto contra Huésped/patología , Humanos , Masculino , Dermatosis del Cuero Cabelludo/patologíaRESUMEN
CD44 is an adhesion molecule involved in many biological functions and has been described to play a role in tumor progression as well as in promotion of metastasis. It has also been suggested that expression of certain CD44 isoforms could be useful for breast and ovarian cancer screening, detection or staging. However, many other reports document no correlation between CD44 isoform expression and tumor malignancy. In light of such contradictory findings, we evaluated by exon-specific RT-PCR whether the expression of CD44 isoforms in breast and ovarian tumors correlated with any of the diagnostic criteria used to assess these diseases. We found a deregulation in the CD44 expression pattern in malignant tumors of both type of cancer compared with the one in benign tumors or normal tissue. However, we could not find a clear correlation between this deregulation or a given CD44 isoform and any diagnostic criteria evaluated, such as age, clinical data, tumor size, hormone receptor status, histological grade or aggressiveness.
Asunto(s)
Empalme Alternativo , Antígenos de Neoplasias/genética , Biomarcadores de Tumor/genética , Neoplasias de la Mama/genética , Receptores de Hialuranos/genética , Neoplasias Ováricas/genética , Isoformas de Proteínas/genética , Adenocarcinoma/química , Adenocarcinoma/genética , Antígenos de Neoplasias/biosíntesis , Biomarcadores de Tumor/biosíntesis , Carcinoma Ductal de Mama/química , Carcinoma Ductal de Mama/genética , Adhesión Celular/genética , Exones/genética , Femenino , Fibroadenoma/química , Fibroadenoma/genética , Humanos , Receptores de Hialuranos/biosíntesis , Papiloma Intraductal/química , Papiloma Intraductal/genética , Pronóstico , Isoformas de Proteínas/biosíntesis , ARN Mensajero/genética , ARN Neoplásico/genética , Reacción en Cadena de la Polimerasa de Transcriptasa InversaRESUMEN
Plasma lipid profile and abdominal obesity have been associated with breast cancer risk, however published results have been inconsistent. To clarify these associations we studied lipid and lipoprotein alterations, obesity degree and body fat distribution, in 30 newly diagnosed breast cancer patients without treatment and 30 controls matched by age and menopausal status. Both pre and postmenopausal breast cancer patients presented higher body mass index, waist/hip ratio and insulin levels than their matched controls. An increase in triglycerides and a decrease in HDL-cholesterol, especially in the HDL2 subfraction, were observed in patients with breast cancer. Besides, HDL particle from these patients showed increased apo A1/HDL-cholesterol ratio. These alterations were correlated with waist/hip ratio. The association between lipoprotein alterations and abdominal obesity independent of menopausal status, in untreated newly diagnosed breast cancer patients is reported for the first time in this study.
